Method for determining and treating amyotrophic lateral sclerosis
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United States of America Patent
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Aug 9, 2016
Grant Date -
Dec 31, 2015
app pub date -
Sep 15, 2015
filing date -
Jun 20, 2011
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Abstract
The present invention provides a method of determining and treating amyotrophic lateral sclerosis (ALS) in a subject, comprising the following steps: (1) measuring a concentration of an autoantibody against high mobility group box 1 protein (HMGB1) in a biological sample from the subject; and (2) administering an effective amount of ALS-treating drug to the subject whose measured concentration of the autoantibody against HMGB1 is higher than 0.874 μg/ml.
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