induces T cell responses against tumoral antigens
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United States of America Patent
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Aug 9, 2016
Grant Date -
May 7, 2009
app pub date -
Sep 12, 2008
filing date -
Nov 21, 2003
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Abstract
An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
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