Particle manipulation system with out-of-plane channel and focusing element

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United States of America Patent

PATENT NO 9404838
SERIAL NO

13998096

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Abstract

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A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. The target particle may be, for example, a stem cell, zygote, a cancer cell, a T-cell, a component of blood, bacteria or DNA sample, for example. The particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the inlet channel.

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Patent Owner(s)

Patent OwnerAddress
MILTENYI BIOTEC INC1201 CLOPPER ROAD GAITHERSBURG MD 20878

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Foster, John S Santa Barbara, US 73 1224
Hoonejani, Mehran R Goleta, US 8 34
Martinez, Nicholas C Santa Barbara, US 7 52
Miltenyi, Stefan Bergische Gladbach, DE 85 1166
Qalandar, Kamala R Ojai, US 3 15
Shields, Kevin E Santa Barbara, US 11 54
Turner, Kimberly L Santa Barbara, US 13 373

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