Therapeutic TRAIL fusion protein and preparation and use thereof
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United States of America Patent
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Aug 2, 2016
Grant Date -
Jul 24, 2014
app pub date -
Jan 27, 2014
filing date -
Jul 28, 2011
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Abstract
This invention relates to the biotechnology area, and provides a kind of TRAIL chimeric protein, DNA sequence encoding this chimeric protein, vectors comprising this DNA, host cells or transgenic animals that contain one of the vectors, and preparation methods for the said chimeric protein and its applications. The said TRAIL fusion protein from the N to C terminal comprises human leucine zipper sequence, human TRAIL protein, human TRAIL extracellular domain or a fragment thereof. The chimeric protein has significantly enhanced stability, prolonged half-life in animals, increased efficacy and thus has broad application future.
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