Viral particles derived from an enveloped virus
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United States of America Patent
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Aug 2, 2016
Grant Date -
May 23, 2013
app pub date -
Oct 26, 2012
filing date -
Oct 27, 2011
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Abstract
The invention relates to generating a vaccine based on immunogens from viral particles that initially have replication competency but are then inactivated by chemical, biophysical or other methods. The components of this vaccine may be a non-HIV enveloped virus that contains and expresses a gene related to the HIV Envelope gene such that the Envelope protein is expressed on the surface of viral particles. These viral particles may be further treated to reduce their replication competency. The vaccine further may contain components to improve its immunogenicity, tolerability, stability and ease of manufacture.
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