Antibodies specific for trop-2 and their uses
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United States of America Patent
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Jul 26, 2016
Grant Date -
Dec 4, 2014
app pub date -
Aug 15, 2014
filing date -
Nov 11, 2011
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Abstract
The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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