Antimicrobial cationic polyamines

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United States of America Patent

PATENT NO 9399044
APP PUB NO 20150342984A1
SERIAL NO

14288782

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Abstract

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Antimicrobial, non-hemolytic cationic polyamines were prepared by treating partially N-acylated polyethylenimines and/or partially oxidized polyethylenimines with a protic acid. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant urea groups, which can be introduced via a cyclic carbonate comprising a pendant urea group. The cationic polyamines can be active against a tuberculosis mycobacterium at low concentration. The cationic polyamines are also effective against Gram-negative Escherichia coli and Pseudomonas aeruginosa, Gram-positive Staphylococcus aureus, and fungus Candida albicans in solution and in the form of a film.

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AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCHSINGAPORE 138632

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  • 2014 Application Filing Year
  • A61K Class
  • 14144 Applications Filed
  • 11600 Patents Issued To-Date
  • 82.02 % Issued To-Date
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Inventor Name Address # of filed Patents Total Citations
Cheng, Wei Singapore, SG 270 548
Ding, Xin Singapore, SG 50 151
Garcia, Jeannette M San Jose, US 123 397
Hedrick, James L Pleasanton, US 297 1330
Yang, Chuan Singapore, SG 77 424
Yang, Yi Yan Singapore, SG 117 520

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  • 11 Citation Count
  • A61K Class
  • 91.06 % this patent is cited more than
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