which form odorous substances and improved biotechnological production methods based thereon

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United States of America Patent

PATENT NO 9394528
APP PUB NO 20070190605A1
SERIAL NO

11616319

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Abstract

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The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesized via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.

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Patent Owner(s)

Patent OwnerAddress
BASF SELUDWIGSHAFEN GERMANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bessler, Cornelius Düsseldorf, DE 28 261
Ehrenreich, Armin Göttingen, DE 3 62
Evers, Stefan Mettmann, DE 40 207
Feesche, Jörg Erkrath, DE 2 0
Gottschalk, Gerhard Nörten-Hardenberg, DE 8 134
Henne, Anke Solingen, DE 3 62
Herzberg, Christina Bilshausen, DE 3 62
Liesegang, Heiko Höxter, DE 3 62
Maurer, Karl-Heinz Erkrath, DE 89 1059
Veith, Birgit Göttingen, DE 7 71

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