Stabilized formulations of peptides and proteins protecting against non-enzymatic degradation
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United States of America Patent
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Jul 19, 2016
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Dec 25, 2014
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Sep 5, 2014
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Dec 21, 2007
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Abstract
Stabilization of water-containing solutions or lyophilizates of proteins and peptide against non-enzymatic deamidation degradation reactions at asparaginyl or glutaminyl residues is achieved using organic anions, such as saccharin, benzenesulfonic acid, gentisic acid or N-acetyltryptophan which have a pKa within the range of 0.5 to 3.5.
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