Silodosin intermediate and preparation method therefor

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United States of America Patent

PATENT NO 9394251
APP PUB NO 20150148548A1
SERIAL NO

14365638

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Abstract

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Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R1 is hydrogen. The formyl group may be a group having the structure shown by the formula I. R7 is a protecting group of carboxyl, and R2 is 3-hydroxypropyl or a group having the structure shown by the formula II. W is a protecting group of hydroxyl. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG JIUZHOU PHARMACEUTICAL CO LTDJIAOJIANG DISTRICT OF TAIZHOU CITY ZHEJIANG PROVINCE 318000 ROAD OUTSIDE NO 99 TAIZHOU CITY ZHEJIANG PROVINCE 318000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Che, Daqing Zhejiang, CN 29 96
Gao, Hongjun Zhejian, CN 14 12
Hu, Xiaowei Zhejiang, CN 21 489
Li, Yuanqiang Zhejiang, CN 18 79
Yan, Pucha Zhejian, CN 2 1
Zhang, Bin Zhejiang, CN 707 5717
Zhang, Xianyi Zhejian, CN 7 3

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