Compounds for targeting drug delivery and enhancing siRNA activity
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United States of America Patent
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Jul 19, 2016
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app pub date -
Jun 8, 2012
filing date -
Jun 8, 2011
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Abstract
Here described are compounds consisting of the structure
wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
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