Monophenols and benzenediols sensitization of immune system against haptenized melanoma antigens
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United States of America Patent
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Jul 19, 2016
Grant Date -
Dec 13, 2012
app pub date -
Jun 11, 2012
filing date -
Jul 28, 2005
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Abstract
The metabolization of certain phenols, monophenols or benzenediols into reactive quinone compounds, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. The compounds function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens to treat malignancies.
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