Methods and dosage forms for controlled delivery of paliperidone and risperidone
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United States of America Patent
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Jul 19, 2016
Grant Date -
Aug 13, 2009
app pub date -
Apr 22, 2009
filing date -
Jul 29, 2002
priority date (Note) -
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Abstract
Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.
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