Cyclic depsipeptide compounds and their uses
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United States of America Patent
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Jul 5, 2016
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Oct 2, 2013
filing date -
Oct 2, 2012
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Abstract
The present invention relates to novel cycloundecadepsipeptide compounds and their analoges which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility. The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analoges for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition of cyclophilin activity.
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