Oxazolidone compound, preparing method and application thereof
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United States of America Patent
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Jul 5, 2016
Grant Date -
Dec 17, 2015
app pub date -
Dec 30, 2013
filing date -
Jan 18, 2013
priority date (Note) -
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Abstract
The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a diastereoisomer and a raceme thereof, and a mixture thereof, and a pharmaceutically acceptable salt thereof, a preparation method thereof, an application thereof as a bioactive substance in a drug. The compound in the present invention has strong anticoagulant activity, does not affect the activity of thrombin, and can reduce the risk of hemorrhage. A pharmacokinetics experiment shows that the compound in the present invention further has good metabolic characteristics, and has a far better oral bioavailability than a positive contrastive agent rivaroxaban.
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