Quinoline and cinnoline derivatives and their applications
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United States of America Patent
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Jul 5, 2016
Grant Date -
Dec 11, 2014
app pub date -
Dec 7, 2012
filing date -
Dec 30, 2011
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Abstract
The present invention relates to a series of quinoline and cinnoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof. And the compounds of general formula I show potent inhibitory activity gainst c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and/or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and/or prevention of cancer.
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