Methods and compositions for the treatment of β-thalassemia
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United States of America Patent
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Jun 28, 2016
Grant Date -
May 21, 2015
app pub date -
Nov 19, 2014
filing date -
Nov 20, 2013
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Abstract
Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
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