Antibodies directed against ICOS and uses thereof

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United States of America Patent

PATENT NO 9376493
APP PUB NO 20140086923A1
SERIAL NO

14008423

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

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Patent Owner(s)

  • CENTRE LEON BERARD;INSTITUT JEAN PAOLI & IRENE CALMETTES;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE CLAUDE BERNARD LYON 1;UNIVERSITE D'AIX-MARSEILLE;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDIACALE)

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Caux, Christophe Lyons, FR 27 189
Faget, Julien Lyons, FR 7 55
Menetrier-Caux, Christine Lyons, FR 12 83
Nunes, Jacques Marseilles, FR 8 60
Olive, Daniel Marseilles, FR 52 375

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