Production of recombinant proteins with simple glycoforms
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United States of America Patent
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Jun 28, 2016
Grant Date -
Nov 27, 2014
app pub date -
Jan 10, 2013
filing date -
Jan 11, 2012
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Abstract
The present invention provides cell lines deficient in mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase I (Mgat1). Also provided are methods for producing the Mga1 deficient cell lines and methods for using the Mgat1 deficient cell lines for the production of recombinant proteins having simple glycoforms.
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