Composition comprising gas-filled microcapsules for ultrasound mediated delivery
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United States of America Patent
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Jun 28, 2016
Grant Date -
Aug 25, 2011
app pub date -
Apr 28, 2011
filing date -
Apr 18, 2005
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Abstract
Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.
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