Small molecule compounds to treat hearing loss
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United States of America Patent
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Jun 21, 2016
Grant Date -
Jan 22, 2015
app pub date -
Feb 22, 2013
filing date -
Feb 24, 2012
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Abstract
The invention is directed, in part, to compositions comprising small molecule compounds to treat or prevent hearing loss. Compositions of the present invention also promote sensory hair cell regeneration. Particular compositions comprise ellipticine derivatives, and optionally one or more small molecules that increase Atoh1 expression or activity, and optionally one or more growth factors.
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