Meganuclease recombination system
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United States of America Patent
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Jun 14, 2016
Grant Date -
Jan 2, 2014
app pub date -
May 22, 2013
filing date -
Oct 23, 2008
priority date (Note) -
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Abstract
The invention relates to a set of genetic constructs which allow the efficient and reproducible introduction of a specific nucleotide sequence at a fixed position in the genome by generating a double strand break at a specific position in the genome using a meganuclease and so stimulating a homologous recombination event at this locus between the genomic site and a transfected donor sequence. The present invention also relates to methods using these constructs and to these materials in the form of a kit.
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