19-NOR neuroactive steroids and methods of use thereof
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United States of America Patent
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Jun 14, 2016
Grant Date -
Mar 24, 2016
app pub date -
Apr 17, 2014
filing date -
Apr 17, 2013
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Abstract
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, and status epilepticus.
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