Crystal form of Dabrafenib and preparation method of use thereof
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United States of America Patent
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Jun 14, 2016
Grant Date -
Oct 29, 2015
app pub date -
Jul 8, 2015
filing date -
Apr 17, 2013
priority date (Note) -
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Abstract
The invention relates to Crystal Hydrate Form VI of Dabrafenib and preparation method thereof, wherein Crystal Hydrate Form VI of Dabrafenib has the advantage of being more stable at room temperature or in aqueous systems, and has low hygroscopicity, and thus is more suitable for a wet granulation process or being prepared into a suspension; and the present invention also relates to a pharmaceutical composition and formulations comprising Crystal Hydrate Form VI of Dabrafenib, and their use in the treatment of Raf family kinase-related diseases.
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