Ultrasound contrast agents and process for the preparation thereof
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United States of America Patent
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Jun 14, 2016
Grant Date -
Mar 9, 2006
app pub date -
Feb 3, 2004
filing date -
Feb 4, 2003
priority date (Note) -
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Abstract
Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.
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