Methods and compositions for enhancing the uptake of therapeutic agents by target cells
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United States of America Patent
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Jun 14, 2016
Grant Date -
May 29, 2014
app pub date -
Mar 28, 2012
filing date -
Mar 28, 2011
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Abstract
The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.
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