Biochemical markers for CVD risk assessment
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United States of America Patent
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Jun 7, 2016
Grant Date -
Dec 23, 2010
app pub date -
Nov 4, 2008
filing date -
Nov 5, 2007
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Abstract
A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.
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