Protein glycosylation modification in methylotrophic yeast
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United States of America Patent
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Jun 7, 2016
Grant Date -
Jun 5, 2014
app pub date -
Jan 10, 2014
filing date -
Jun 30, 2000
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Abstract
The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an α-1,2-mannosidase and glucosidase II. The genetically engineered strains of the present invention can be further modified such that the OCH1 gene is disrupted. Methods of producing glycoproteins with reduced glycosylation using such genetically engineered stains of Pichia are also provided.
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