DNA vaccines and methods for the prevention of transplantation rejection
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United States of America Patent
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Jun 7, 2016
Grant Date -
Dec 6, 2012
app pub date -
Jul 6, 2012
filing date -
May 11, 2005
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Abstract
Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
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