Treatment of sepsis using complement inhibitors
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United States of America Patent
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Jun 7, 2016
Grant Date -
Feb 28, 2013
app pub date -
Feb 25, 2011
filing date -
Feb 25, 2010
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Abstract
Methods for the treatment of sepsis with complement inhibitors are disclosed. In particular, C3 inhibitors, such as Compstatin and Compstatin analogs, are administered at various times following the onset of sepsis to alleviate tissue damage and organ failure, which are hallmarks of the second, extravascular stage of sepsis. Combination therapies for comprehensive treatment of sepsis are also disclosed. Pharmaceutical compositions and kits for use in the methods are disclosed as well.
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