Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
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United States of America Patent
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May 31, 2016
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Jan 15, 2013
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Dec 30, 2003
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Abstract
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
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