Preparation method for rivastigmine, intermediates thereof, and preparation method for said intermediates

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United States of America Patent

PATENT NO 9353049
APP PUB NO 20140073809A1
SERIAL NO

14118411

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Abstract

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The present invention provides a preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate, preparation methods for intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, as well as a method for using (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium to prepare rivastigmine which can be used for the treatment of Alzheimer's disease.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG HISUN PHARMACEUTICAL CO LTDJIAOJIANG DISTRICT OF TAIZHOU CITY ZHEJIANG PROVINCE 318000 ROAD OUTSIDE NO 46 TAIZHOU CITY ZHEJIANG PROVINCE 318000
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY200040 NO 1320 WEST BEIJING ROAD SHANGHAI SHANGHAI CITY SHANGHAI CITY 200040

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bai, Hua Zhejiang, CN 113 414
Chen, Daoxin Zhejiang, CN 2 1
Sun, Rentong Zhejiang, CN 2 1
Yang, Chunbo Shanghai, CN 8 17
Yang, Zhezhou Shanghai, CN 4 1
Yang, Zhiqing Zhejiang, CN 12 8
Zhang, Fuli Shanghai, CN 12 4

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