Trialkyl cationic lipids and methods of use thereof
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United States of America Patent
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May 31, 2016
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Feb 22, 2013
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Feb 24, 2012
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Abstract
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.
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