Reprogramming T cells and hematopoietic cells
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United States of America Patent
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May 24, 2016
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app pub date -
Apr 22, 2014
filing date -
Jun 5, 2009
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Abstract
Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
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