Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
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United States of America Patent
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May 24, 2016
Grant Date -
Jan 29, 2015
app pub date -
Oct 13, 2014
filing date -
Dec 7, 2005
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Abstract
A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another β-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).
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