Reconstituted human breast tumor model
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United States of America Patent
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May 24, 2016
Grant Date -
Jun 8, 2006
app pub date -
Jun 28, 2005
filing date -
Dec 7, 2004
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Abstract
A reconstituted human breast tumor model is disclosed. The model, which is incorporated into mice, provides actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain a recombinant human oncogene and an SV40 early region.
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