Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof

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United States of America Patent

PATENT NO 9340566
SERIAL NO

14628373

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Abstract

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The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.

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Patent Owner(s)

Patent OwnerAddress
METABASIS THERAPEUTICS INC9390 TOWNE CENTRE DRIVE SAN DIEGO CA 92121

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bookser, Brett C San Diego, US 21 72
Boyer, Serge H San Diego, US 16 326
Erion, Mark D Del Mar, US 67 1993
Hecker, Scott J Del Mar, US 57 306
Mali, Venkat Reddy Cupertino, US 56 249
Raffaele, Nicholas Brian San Diego, US 7 10
Reddy, K Raja San Diego, US 46 911
Stebbins, Jeff San Diego, US 4 5

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