Method for removing FMOC group

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United States of America Patent

PATENT NO 9334302
APP PUB NO 20140296483A1
SERIAL NO

14305841

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Abstract

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The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I):

description='In-line Formulae' end='lead'HS-L-COOH  (I)description='In-line Formulae' end='tail'

wherein L is a C1-8 alkylene group optionally having substituent(s), an amino group-containing compound protected by an Fmoc group, and a base to give a reaction mixture containing a compound represented by the formula (II):

description='In-line Formulae' end='lead'Fm—S-L-COOH  (II)description='In-line Formulae' end='tail'

wherein Fm is a 9-fluorenylmethyl group, and L is as mentioned above, and an amino group-containing compound, and a step of removing the compound represented by the formula (II) by washing the obtained reaction mixture with a basic aqueous solution. According to the present invention, a removal method of Fmoc group, which can remove a dibenzofulvene derivative as a byproduct with ease, can be provided.

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Patent Owner(s)

Patent OwnerAddress
AJINOMOTO CO INCJAPAN TOKYO CENTRAL BEIJING A CHOME 15-1 TOKYO TOKYO METROPOLIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Takahashi, Daisuke Yokkaichi, JP 266 1309

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