Compositions of asymmetric interfering RNA and uses thereof
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United States of America Patent
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May 3, 2016
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Aug 20, 2009
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Aug 27, 2008
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Aug 27, 2007
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Abstract
The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5′-overhang, 3′-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
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