Anti-CDH3 antibody having high internalization capacity
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United States of America Patent
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May 3, 2016
Grant Date -
Nov 28, 2013
app pub date -
Oct 28, 2011
filing date -
Oct 29, 2010
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Abstract
It is an object of the present invention to provide an anti-cadherin antibody having a high internalization capacity and provide an anti-cadherin antibody-drug conjugate that effectively kills cadherin-expressing cancer cells with the use of such antibody. The present invention provides an anti-cadherin antibody which recognizes a cadherin domain 1 (EC1) of cadherin and exhibits a high internalization capacity.
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