Modified anti-heparin/PF4 complex antibody and HIT antibody standard
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United States of America Patent
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Apr 26, 2016
Grant Date -
Jul 14, 2011
app pub date -
Aug 26, 2009
filing date -
Aug 27, 2008
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Abstract
Provided is a modified antibody which enables the quantitative measurement of the amount of a heparin/PF4 complex, an onset factor of heparin-induced trombocytopenia (HIT), without the influence of the presence of PF4, and which can be used as an HIT antibody standard specific for the heparin/PF4 complex. The modified antibody is prepared by linking a human IgG, or an antibody fragment derived from a human IgG, to a monoclonal antibody obtained by immunizing an animal (excluding a human) with the heparin/PF4 complex.
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