MicroRNA-based methods and assays for osteosarcoma

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United States of America Patent

PATENT NO 9322016
APP PUB NO 20140243392A1
SERIAL NO

14240178

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Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

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Patent OwnerAddress
3-D MATRIX LTDCHIYODA-KU TOKYO 102-0083

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujiwara, Tomohiro Tokyo, JP 7 18
Ochiya, Takahiro Tokyo, JP 86 233

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