Homo- and heterodimeric SMAC mimetic compounds as apoptosis inducers
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United States of America Patent
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Apr 26, 2016
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Apr 30, 2015
app pub date -
Feb 20, 2012
filing date -
Feb 20, 2012
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Abstract
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
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