Methods of treatment using alpha-1-antitrypsin compositions

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United States of America Patent

PATENT NO 9320783
SERIAL NO

14802885

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Abstract

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A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Separation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

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Patent Owner(s)

Patent OwnerAddress
CSL BEHRING L L C1020 FIRST AVENUE KING OF PRUSSIA PENNSYLVANIA 19406-0901 19406-0901

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cook, Paul I Kankakee, US 8 42
Fowler, Scott A Apex, US 10 48
Kee, Scott M Bourbonnais, US 11 57
Kling, Robert Bourbonnais, US 71 1554
Smith, James R Bourbonnais, US 66 763
Weber, David Bradley, US 62 1037

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