Therapeutic and diagnostic molecules

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United States of America Patent

PATENT NO 9320755
APP PUB NO 20120196925A1
SERIAL NO

13376304

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.

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Patent Owner(s)

Patent OwnerAddress
CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGYMISSENDEN ROAD NEW SOUTH WALES CAMPERDOWN 2050

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gamble, Jennifer Double Bay, AU 11 33
Goodall, Gregory Netherby, AU 3 0
Vadas, Mathew Double Bay, AU 12 33
Young, Jennifer Petersham, AU 8 11

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