Cell-specifically effective molecules on the basis of siRNA and application kits for the production thereof and use thereof
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United States of America Patent
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Apr 19, 2016
Grant Date -
Dec 29, 2011
app pub date -
Mar 12, 2010
filing date -
Feb 13, 2008
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Abstract
A biologically inactivated cell-specifically effective molecule for biologically inactive transfection into a target cell to inhibit expression of genes in the target cell after biological activation of the molecule, by bonding to mRNA and with the formation of a RISC complex, the biologically inactivated cell-specifically effective molecule comprising siRNA coupled with at least one peptide via a linker which remains at the siRNA after biological activation of the molecule, the linker comprising an amino Cn linker wherein n is an integer of 1-6. Kits include the molecule or the constituents thereof and transfection reagents in ampoules and injection equipment for injecting mixtures of the ampoule contents into a medium containing a target cell.
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