Method of inhibiting ABCG2 and other treatment methods
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United States of America Patent
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Apr 19, 2016
Grant Date -
Oct 17, 2013
app pub date -
Jun 5, 2013
filing date -
Jan 3, 2008
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Abstract
Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I):
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