Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage

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United States of America Patent

PATENT NO 9308277
SERIAL NO

13029891

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The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.

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Patent OwnerAddress
MESOBLAST INTERNATIONAL SÀRLROUTE DE PRE-BOIS 20 MEYRIN 1217

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Qiu, Yan Jamaica Plain, US 24 105
Sandrasagra, Anthony Arlington, US 16 299
Segers, Vincent Frans Maria Bornem, BE 3 8

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