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United States of America Patent
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Mar 29, 2016
Grant Date -
Aug 19, 2010
app pub date -
Aug 25, 2008
filing date -
Aug 23, 2007
priority date (Note) -
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Abstract
A process for isolation and purification of a target protein by chromatography wherein the chromatography removes or depletes prions (PrPSC), comprising the steps of contacting a potentially PrPSC contaminated sample comprising a target protein with a multimodal chromatographic material; setting buffer conditions so that the target protein is bound to the multimodal chromatographic material and whereas PrPSC is not binding to the multimodal chromatographic material; followed by elution of the target protein. a process for isolation and purification of a target protein free of prion protein (prpSC).
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