Direct clone analysis and selection technology
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United States of America Patent
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Mar 22, 2016
Grant Date -
Jul 25, 2013
app pub date -
Jul 13, 2011
filing date -
Jul 13, 2010
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Abstract
The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time.
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